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Thyroid peroxidase : ウィキペディア英語版 | Thyroid peroxidase
Thyroid peroxidase or thyroperoxidase (TPO) is an enzyme expressed mainly in the thyroid where it is secreted into colloid. Thyroid peroxidase oxidizes iodide ions to form iodine atoms for addition onto tyrosine residues on thyroglobulin for the production of thyroxine (T4) or triiodothyronine (T3), the thyroid hormones. In humans, thyroperoxidase is encoded by the ''TPO'' gene. == Catalyzed reaction ==
+ I− + H+ + H2O2 ⇒ + 2 H2O Iodide is oxidized to iodine radical which immediately reacts with tyrosine. + I− + H+ + H2O2 ⇒ + 2 H2O The second iodine atom is added in similar manner to the reaction intermediate 3-iodotyrosine.
抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「Thyroid peroxidase」の詳細全文を読む
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